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Lixte Biotechnology Holdings Inc is a clinical-stage biotechnology company developing cancer therapies based on protein phosphatase inhibition. The company’s research is focused on protein phosphatase 2A, or PP2A, a cellular enzyme involved in signaling pathways that can influence tumor growth, DNA damage response, and cancer cell survival. Rather than operating as a commercial drugmaker, Lixte is primarily engaged in research, development, clinical testing, and the pursuit of regulatory pathways for its drug candidates.

Its lead compound is LB-100, a PP2A inhibitor being studied for its potential to make cancer cells more vulnerable to established treatments. The therapeutic strategy is to use LB-100 in combination with other anti-cancer approaches, including chemotherapy, radiation therapy, immune checkpoint inhibitors, and other cytotoxic or targeted agents. By attempting to enhance the effects of existing treatments, Lixte is targeting areas where outcomes remain poor and where combination regimens are common in oncology development.

The company has identified ovarian clear cell carcinoma and metastatic colorectal cancer among the indications of interest for LB-100. These are serious cancer settings with significant unmet medical need, particularly for patients whose disease does not respond adequately to standard therapy. As with many early and clinical-stage biotechnology companies, Lixte’s value is closely tied to trial progress, safety results, efficacy signals, intellectual property, financing capacity, and potential partnerships.

Lixte operates in a single reportable segment: the development of cancer treatments. It does not have a diversified commercial product portfolio, so its investment profile is highly dependent on the advancement of its pipeline and the broader oncology drug-development landscape.

3.74USD
−0.56(-13.00%)

Last updated

Market Cap
$78,622,834
P/E
P/FCF
P/S
Enterprise Value
Sector
Materials
Industry
Pharmaceutical Preparations
Address
433 PLAZA REAL, BOCA RATON, FL, 33432
Market Cap
$78,622,834
Enterprise Value
P/E
P/B
P/S
EV / EBITDA
EV / Sales
EPS
Dividend Yield
P/FCF
P/CF
Free Cash Flow
ROE
ROA
Debt / Equity
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Avg Volume
Fundamentals Snapshot Price

Income Statement

Line Item2025 Q42024 Q42023 Q42022 Q42021 Q4
Cost of revenue00000
Gross profit0
Operating income-5.11M-3.57M-5.09M-6.31M-6.72M
EBITDA-5.11M-3.57M-5.09M-6.31M-6.72M
Net income-6.08M-3.59M-5.09M-6.31M-6.73M
Interest expense-9.16K-16.82K-16.23K-8.88K-7.41K
Other operating expenses0001.15M1.23M
Total operating expenses5.11M3.57M5.09M6.31M6.72M
Basic EPS-1.26-1.59-2.66-3.99-5
Diluted EPS-1.26-1.59-2.66-3.99-5

Balance Sheet

Line Item2025 Q42024 Q42023 Q42022 Q42021 Q4
Total assets12.73M1.15M4.31M5.56M5.09M
Total liabilities1.77M318.28K313.86K395.76K302.93K
Total equity10.96M827.22K3.99M5.17M4.79M
Cash & equivalents5.11M1.04M4.2M5.35M4.82M
Current assets5.18M1.15M4.31M5.56M5.09M
Current liabilities1.33M318.28K313.86K395.76K302.93K
Accounts payable436.48K83.21K156.76K230.73K225.97K
Receivables00000

Cash Flow

Line Item2025 Q42024 Q42023 Q42022 Q42021 Q4
Operating cash flow-3.07M-3.16M-4.29M-4.61M-4.14M
Investing cash flow-3.17M
Financing cash flow10.31M3.14M5.14M3.9M
Change in cash4.07M-3.16M-1.15M529.65K-245.52K
Net income-6.01M-3.59M-5.09M-6.31M-6.73M
KindFilingDateLink
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edgar index8-K — NOMAD POWER SOLUTIONS, INC.View Filing
eight k text8-K — 8-KView Filing
edgar index3 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
eight k text8-K — 8-KView Filing
form 4Form 4 — Felix LourdesView Filing
form 4Form 4 — Holloway Michael AndrewView Filing
form 4Form 4 — Primus Guy WarrenView Filing
form 4Form 4 — Pursglove Geordan GarrettView Filing
form 4Form 4 — Sawyer Jason DavidView Filing
form 4Form 4 — Stazzone PeterView Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
eight k text8-K — 8-KView Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
eight k text8-K — 8-KView Filing
edgar indexSCHEDULE 13G — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index424B5 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
eight k text8-K — 8-KView Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index3 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
eight k text8-K — 8-KView Filing
form 4Form 4 — Porter Stuart DView Filing
edgar index10-Q — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
eight k text8-K — 8-KView Filing
form 4Form 4 — Felix LourdesView Filing
form 4Form 4 — Felix LourdesView Filing
form 4Form 4 — Holloway Michael AndrewView Filing
form 4Form 4 — Holloway Michael AndrewView Filing
form 4Form 4 — Primus Guy WarrenView Filing
form 4Form 4 — Primus Guy WarrenView Filing
form 4Form 4 — Pursglove Geordan GarrettView Filing
form 4Form 4 — Pursglove Geordan GarrettView Filing
form 4Form 4 — Sawyer Jason DavidView Filing
form 4Form 4 — Sawyer Jason DavidView Filing
form 4Form 4 — Stazzone PeterView Filing
form 4Form 4 — Stazzone PeterView Filing
edgar index10-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
ten k section10-K — businessView Filing
ten k section10-K — mdaView Filing
ten k section10-K — risk_factorsView Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
eight k text8-K — 8-KView Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
form 4Form 4 — Felix LourdesView Filing
form 4Form 4 — Primus Guy WarrenView Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index424B5 — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing
edgar index25-NSE/A — LIXTE BIOTECHNOLOGY HOLDINGS, INC.View Filing