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Lixte Biotechnology Holdings Inc is a clinical-stage biotechnology company developing cancer therapies based on protein phosphatase inhibition. The company’s research is focused on protein phosphatase 2A, or PP2A, a cellular enzyme involved in signaling pathways that can influence tumor growth, DNA damage response, and cancer cell survival. Rather than operating as a commercial drugmaker, Lixte is primarily engaged in research, development, clinical testing, and the pursuit of regulatory pathways for its drug candidates.
Its lead compound is LB-100, a PP2A inhibitor being studied for its potential to make cancer cells more vulnerable to established treatments. The therapeutic strategy is to use LB-100 in combination with other anti-cancer approaches, including chemotherapy, radiation therapy, immune checkpoint inhibitors, and other cytotoxic or targeted agents. By attempting to enhance the effects of existing treatments, Lixte is targeting areas where outcomes remain poor and where combination regimens are common in oncology development.
The company has identified ovarian clear cell carcinoma and metastatic colorectal cancer among the indications of interest for LB-100. These are serious cancer settings with significant unmet medical need, particularly for patients whose disease does not respond adequately to standard therapy. As with many early and clinical-stage biotechnology companies, Lixte’s value is closely tied to trial progress, safety results, efficacy signals, intellectual property, financing capacity, and potential partnerships.
Lixte operates in a single reportable segment: the development of cancer treatments. It does not have a diversified commercial product portfolio, so its investment profile is highly dependent on the advancement of its pipeline and the broader oncology drug-development landscape.
Last updated
- Market Cap
- $78,622,834
- P/E
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- P/FCF
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- P/S
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- Enterprise Value
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- Sector
- Materials
- Industry
- Pharmaceutical Preparations
- Address
- 433 PLAZA REAL, BOCA RATON, FL, 33432
The New Bottleneck Isn’t Computing Power — It’s Just Power
LIXTE Biotechnology Attending the DealFlow Discovery Conference, January 28-29
Spartan Capital Securities, LLC Serves as Placement Agent in Lixte Biotechnology Holdings, Inc.’s $4.3 Million Registered Direct Offering
24/7 Market News: LIXTE Biotech Advances Precision Oncology Pipeline with First Phase 1B/2 Trial Readout Expected in 2H 2025
- Market Cap
Market cap is the total value of a company's shares, calculated by multiplying the stock price by the number of shares outstanding.
- $78,622,834
- Enterprise Value
Enterprise value is the total value of a company, including its market cap, debt, and cash.
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- P/E
P/E ratio compares a company's share price to its earnings per share.
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- P/B
P/B ratio compares a company's share price to its book value per share.
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- P/S
P/S ratio compares a company's share price to its revenue per share.
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- EV / EBITDA
EV/EBITDA measures a company's value compared to its earnings before interest, taxes, depreciation, and amortization.
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- EV / Sales
EV/Sales measures a company's value compared to its total revenue.
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- EPS
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- Dividend Yield
Dividend yield shows how much a company pays in dividends each year compared to its share price.
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- P/FCF
Price-to-free-cash-flow ratio compares a company's share price to the cash it generates after expenses and investments.
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- P/CF
P/CF ratio compares a company's share price to the cash flow it generates from its operations.
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- Free Cash Flow
Free cash flow is the cash a company has left after covering operating costs and capital expenses.
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- ROE
ROE measures how effectively a company uses shareholders' equity to generate profit.
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- ROA
ROA measures how effectively a company uses its assets to generate profit.
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- Debt / Equity
Debt-to-equity ratio compares a company's total debt to its shareholders' equity.
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- Current Ratio
Current ratio measures a company's ability to pay short-term debts using its short-term assets.
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- Quick Ratio
Quick ratio measures a company's ability to pay short-term debts using cash and other easily available assets.
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- Cash
Cash ratio measures a company's ability to cover short-term debts using only cash and cash equivalents.
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- Avg Volume
Average volume shows the average number of shares traded over the last 30 trading days, helping indicate liquidity.
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- Fundamentals Snapshot Price
Fundamentals snapshot price is the stock price used when calculating the company's financial ratios and metrics.
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Income Statement
| Line Item | 2025 Q4 | 2024 Q4 | 2023 Q4 | 2022 Q4 | 2021 Q4 |
|---|---|---|---|---|---|
| Cost of revenue | 0 | 0 | 0 | 0 | 0 |
| Gross profit | — | — | — | — | 0 |
| Operating income | -5.11M | -3.57M | -5.09M | -6.31M | -6.72M |
| EBITDA | -5.11M | -3.57M | -5.09M | -6.31M | -6.72M |
| Net income | -6.08M | -3.59M | -5.09M | -6.31M | -6.73M |
| Interest expense | -9.16K | -16.82K | -16.23K | -8.88K | -7.41K |
| Other operating expenses | 0 | 0 | 0 | 1.15M | 1.23M |
| Total operating expenses | 5.11M | 3.57M | 5.09M | 6.31M | 6.72M |
| Basic EPS | -1.26 | -1.59 | -2.66 | -3.99 | -5 |
| Diluted EPS | -1.26 | -1.59 | -2.66 | -3.99 | -5 |
Balance Sheet
| Line Item | 2025 Q4 | 2024 Q4 | 2023 Q4 | 2022 Q4 | 2021 Q4 |
|---|---|---|---|---|---|
| Total assets | 12.73M | 1.15M | 4.31M | 5.56M | 5.09M |
| Total liabilities | 1.77M | 318.28K | 313.86K | 395.76K | 302.93K |
| Total equity | 10.96M | 827.22K | 3.99M | 5.17M | 4.79M |
| Cash & equivalents | 5.11M | 1.04M | 4.2M | 5.35M | 4.82M |
| Current assets | 5.18M | 1.15M | 4.31M | 5.56M | 5.09M |
| Current liabilities | 1.33M | 318.28K | 313.86K | 395.76K | 302.93K |
| Accounts payable | 436.48K | 83.21K | 156.76K | 230.73K | 225.97K |
| Receivables | 0 | 0 | 0 | 0 | 0 |
Cash Flow
| Line Item | 2025 Q4 | 2024 Q4 | 2023 Q4 | 2022 Q4 | 2021 Q4 |
|---|---|---|---|---|---|
| Operating cash flow | -3.07M | -3.16M | -4.29M | -4.61M | -4.14M |
| Investing cash flow | -3.17M | — | — | — | — |
| Financing cash flow | 10.31M | — | 3.14M | 5.14M | 3.9M |
| Change in cash | 4.07M | -3.16M | -1.15M | 529.65K | -245.52K |
| Net income | -6.01M | -3.59M | -5.09M | -6.31M | -6.73M |
| Kind | Filing | Date | Link |
|---|---|---|---|
| edgar index | 8-K — NOMAD POWER SOLUTIONS, INC. | View Filing | |
| edgar index | SCHEDULE 13G — NOMAD POWER SOLUTIONS, INC. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| edgar index | DEF 14A — NOMAD POWER SOLUTIONS, INC. | View Filing | |
| edgar index | PRE 14A — NOMAD POWER SOLUTIONS, INC. | View Filing | |
| edgar index | 8-K — NOMAD POWER SOLUTIONS, INC. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| edgar index | 3 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| form 4 | Form 4 — Felix Lourdes | View Filing | |
| form 4 | Form 4 — Holloway Michael Andrew | View Filing | |
| form 4 | Form 4 — Primus Guy Warren | View Filing | |
| form 4 | Form 4 — Pursglove Geordan Garrett | View Filing | |
| form 4 | Form 4 — Sawyer Jason David | View Filing | |
| form 4 | Form 4 — Stazzone Peter | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| edgar index | SCHEDULE 13G — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 424B5 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 3 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| form 4 | Form 4 — Porter Stuart D | View Filing | |
| edgar index | 10-Q — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| form 4 | Form 4 — Felix Lourdes | View Filing | |
| form 4 | Form 4 — Felix Lourdes | View Filing | |
| form 4 | Form 4 — Holloway Michael Andrew | View Filing | |
| form 4 | Form 4 — Holloway Michael Andrew | View Filing | |
| form 4 | Form 4 — Primus Guy Warren | View Filing | |
| form 4 | Form 4 — Primus Guy Warren | View Filing | |
| form 4 | Form 4 — Pursglove Geordan Garrett | View Filing | |
| form 4 | Form 4 — Pursglove Geordan Garrett | View Filing | |
| form 4 | Form 4 — Sawyer Jason David | View Filing | |
| form 4 | Form 4 — Sawyer Jason David | View Filing | |
| form 4 | Form 4 — Stazzone Peter | View Filing | |
| form 4 | Form 4 — Stazzone Peter | View Filing | |
| edgar index | 10-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| ten k section | 10-K — business | View Filing | |
| ten k section | 10-K — mda | View Filing | |
| ten k section | 10-K — risk_factors | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 4 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| form 4 | Form 4 — Felix Lourdes | View Filing | |
| form 4 | Form 4 — Primus Guy Warren | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 424B5 — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 8-K — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing | |
| edgar index | 25-NSE/A — LIXTE BIOTECHNOLOGY HOLDINGS, INC. | View Filing |