Milestone Pharmaceuticals (MIST)
Nasdaq Market Open
Milestone Pharmaceuticals Inc. is a biopharmaceutical company centred on cardiovascular medicines, with a particular focus on episodic conditions that may benefit from rapid, patient-administered treatment outside the hospital. Its business is built around etripamil, a calcium channel blocker formulated as a nasal spray and commercialised in the United States under the CARDAMYST brand.
CARDAMYST is designed for people with paroxysmal supraventricular tachycardia, or PSVT, a condition marked by sudden episodes of abnormally fast heart rhythm that can cause palpitations, dizziness, shortness of breath, chest discomfort, and anxiety. Traditional management of acute PSVT often involves medical supervision, vagal manoeuvres, emergency care, or intravenous therapy. Milestone’s approach is distinctive because it aims to give appropriate patients a portable treatment option that can be used when an attack occurs, rather than requiring immediate administration in a clinical setting.
The company’s strategy combines drug development, regulatory execution, and commercial preparation in a single specialised area of cardiovascular care. By focusing on a defined arrhythmia population, Milestone seeks to address a practical gap between chronic prevention and emergency intervention. The nasal delivery route is central to the product’s positioning, as it is intended to provide a non-invasive and convenient means of administering therapy during intermittent episodes.
Milestone operates as one reportable segment, reflecting its narrow concentration on cardiovascular product development and commercialisation. For investors, the company offers exposure to a targeted specialty pharmaceutical model. Its prospects depend on physician adoption, patient education, reimbursement, post-approval evidence, and the broader acceptance of self-administered acute therapy for PSVT.
Last updated
- Market Cap
- 160.6M
- P/E
- —
- P/FCF
- —
- P/S
- 90.02
- Enterprise Value
- 225.59M
- Sector
- Health Care
- Industry
- Pharmaceutical Preparations
- Address
- 1111 BOUL. DR.-FREDERIK-PHILIPS, STE 420, MONTREAL, A8, H4M 2X6
Milestone Pharmaceuticals Announces RESET-PSVT Registry to Generate Real-World Evidence on CARDAMYST™ (etripamil) Nasal Spray in Patients With PSVT
Milestone Receives FDA Approval of CARDAMYST™ (etripamil) as First and Only Self-Administered Nasal Spray for Adults with Paroxysmal Supraventricular Tachycardia (PSVT)
Milestone Pharmaceuticals to Present New Analysis from Investigational Etripamil Nasal Spray Clinical Trials for PSVT at the American Heart Association Scientific Sessions 2025
Milestone® Pharmaceuticals to Present Data on Etripamil at the American Heart Association Scientific Sessions 2025
Atrial Fibrillation (AF) Pipeline Market Research Report 2025 | Insights on 10+ Companies and 12+ Drugs in the Pipeline Landscape
Milestone Pharmaceuticals Announces FDA Acceptance of the Company’s Response to the CRL for CARDAMYST™ (etripamil) Nasal Spray
Milestone Partner Ji Xing Pharmaceuticals Ltd Announces Positive Topline Results from the Phase 3 Study of Etripamil in PSVT in China
Milestone Pharmaceuticals to Host KOL Event for Investors “Learnings from the Field: Expert Perspectives on PSVT in the Community Setting” on June 20, 2024
Milestone® Pharmaceuticals to Participate in the Upcoming Jefferies Global Healthcare Conference
Milestone Pharmaceuticals Announces FDA Acceptance of New Drug Application for CARDAMYST™
Milestone Pharmaceuticals (MIST) Upgraded to Buy: Here's What You Should Know
Milestone Pharmaceuticals Reports First Quarter 2024 Financial Results and Provides Regulatory and Corporate Update
Milestone® Pharmaceuticals to Present Data on Etripamil at the Preventative Cardiovascular Nursing Symposium
Milestone® Pharmaceuticals Announces Etripamil Data Demonstrating Patients’ Ability to Self-Manage Recurring PSVT, Presented at The American College of Cardiology Annual Meeting
Milestone® Pharmaceuticals to Present Data on Etripamil at the American College of Cardiology and European Heart Rhythm Association Annual Conferences
Milestone Pharmaceuticals Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Regulatory and Corporate Update
Milestone® Pharmaceuticals to Participate in a Corporate Panel Discussion at TD Cowen 44th Annual Health Care Conference
Milestone Pharmaceuticals Announces Pricing of $30.0 Million Public Offering of Common Shares and Pre-Funded Warrants
Milestone Pharmaceuticals Announces Proposed Public Offering of Common Shares and Pre-Funded Warrants
Down -43.64% in 4 Weeks, Here's Why Milestone Pharmaceuticals (MIST) Looks Ripe for a Turnaround
- Market Cap
Market cap is the total value of a company's shares, calculated by multiplying the stock price by the number of shares outstanding.
- 160.6M
- Enterprise Value
Enterprise value is the total value of a company, including its market cap, debt, and cash.
- 225.59M
- P/E
P/E ratio compares a company's share price to its earnings per share.
- —
- P/B
P/B ratio compares a company's share price to its book value per share.
- -8.19
- P/S
P/S ratio compares a company's share price to its revenue per share.
- 90.02
- EV / EBITDA
EV/EBITDA measures a company's value compared to its earnings before interest, taxes, depreciation, and amortization.
- -3.46
- EV / Sales
EV/Sales measures a company's value compared to its total revenue.
- 126.45
- EPS
- -0.55
- Dividend Yield
Dividend yield shows how much a company pays in dividends each year compared to its share price.
- 0%
- P/FCF
Price-to-free-cash-flow ratio compares a company's share price to the cash it generates after expenses and investments.
- —
- P/CF
P/CF ratio compares a company's share price to the cash flow it generates from its operations.
- —
- Free Cash Flow
Free cash flow is the cash a company has left after covering operating costs and capital expenses.
- -51.48M
- ROE
ROE measures how effectively a company uses shareholders' equity to generate profit.
- 348.79%
- ROA
ROA measures how effectively a company uses its assets to generate profit.
- -35.29%
- Debt / Equity
Debt-to-equity ratio compares a company's total debt to its shareholders' equity.
- -6.95
- Current Ratio
Current ratio measures a company's ability to pay short-term debts using its short-term assets.
- 9.18
- Quick Ratio
Quick ratio measures a company's ability to pay short-term debts using cash and other easily available assets.
- 9.09
- Cash
Cash ratio measures a company's ability to cover short-term debts using only cash and cash equivalents.
- 3.41
- Avg Volume
Average volume shows the average number of shares traded over the last 30 trading days, helping indicate liquidity.
- 1.3M
- Fundamentals Snapshot Price
Fundamentals snapshot price is the stock price used when calculating the company's financial ratios and metrics.
- 1.29
Income Statement
| Line Item | 2026 Q1 | 2025 Q4 | 2025 Q3 | 2025 Q2 | 2025 Q1 |
|---|---|---|---|---|---|
| Revenue | 238K | 1.55M | — | — | — |
| Gross profit | 224K | 1.55M | — | — | — |
| Operating income | -23.66M | -17.26M | -11.83M | -12.53M | -20.52M |
| EBITDA | -23.61M | -17.22M | -11.8M | -12.5M | -20.5M |
| Net income | -26.07M | -17.41M | -11.92M | -12.97M | -20.76M |
| Basic EPS | -0.2 | -0.15 | -0.12 | -0.2 | -0.31 |
| Diluted EPS | -0.2 | -0.15 | -0.12 | -0.2 | -0.31 |
Balance Sheet
| Line Item | 2026 Q1 | 2025 Q4 | 2025 Q3 | 2025 Q2 | 2025 Q1 |
|---|---|---|---|---|---|
| Total assets | 193.73M | 113.56M | 87.75M | 47.42M | 61.89M |
| Total liabilities | 213.33M | 127.44M | 122.9M | 65.16M | 121.08M |
| Total equity | -19.6M | -13.88M | -35.15M | -17.75M | -59.2M |
| Cash & equivalents | 71.32M | 73.05M | 46.69M | 42.5M | 45.09M |
| Current assets | 192.25M | 111.92M | 86.67M | 46.17M | 60.48M |
| Current liabilities | 20.94M | 13.98M | 10.52M | 9.28M | 12.96M |
Cash Flow
| Line Item | 2026 Q1 | 2025 Q4 | 2025 Q3 | 2025 Q2 | 2025 Q1 |
|---|---|---|---|---|---|
| Operating cash flow | -16.05M | -12.78M | -9.75M | -12.57M | -13.95M |
| Investing cash flow | -80.03M | 2.7M | -34.98M | 9.94M | 33.58M |
| Financing cash flow | 94.35M | 36.43M | 48.92M | 36K | 140K |
| Change in cash | -1.73M | 26.36M | 4.19M | -2.59M | 19.77M |
| Kind | Filing | Date | Link |
|---|---|---|---|
| edgar index | EFFECT — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | SCHEDULE 13G/A — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | SCHEDULE 13G/A — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 10-Q — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 8-K — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | S-3 — Milestone Pharmaceuticals Inc. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 144 — Milestone Pharmaceuticals Inc. | View Filing | |
| form 4 | Form 4 — Oliveto Joseph | View Filing | |
| edgar index | SCHEDULE 13G/A — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 3 — Milestone Pharmaceuticals Inc. | View Filing | |
| form 3 | Form 3 — Sandoval David I. | View Filing | |
| edgar index | 10-K — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 8-K — Milestone Pharmaceuticals Inc. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| ten k section | 10-K — business | View Filing | |
| ten k section | 10-K — mda | View Filing | |
| ten k section | 10-K — risk_factors | View Filing | |
| edgar index | 4/A — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4/A — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4/A — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4/A — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4/A — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| form 4 | Form 4 — Oliveto Joseph | View Filing | |
| form 4 | Form 4 — Oliveto Joseph | View Filing | |
| form 4 | Form 4 — Oliveto Joseph | View Filing | |
| form 4 | Form 4 — Muller Lorenz | View Filing | |
| form 4 | Form 4 — Muller Lorenz | View Filing | |
| form 4 | Form 4 — Muller Lorenz | View Filing | |
| form 4 | Form 4 — Hasija Amit | View Filing | |
| form 4 | Form 4 — Hasija Amit | View Filing | |
| form 4 | Form 4 — Hasija Amit | View Filing | |
| form 4 | Form 4 — Bharucha David | View Filing | |
| form 4 | Form 4 — Bharucha David | View Filing | |
| form 4 | Form 4 — Bharucha David | View Filing | |
| form 4 | Form 4 — Nelson Jeffrey Edward | View Filing | |
| form 4 | Form 4 — Nelson Jeffrey Edward | View Filing | |
| form 4 | Form 4 — Nelson Jeffrey Edward | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 8-K — Milestone Pharmaceuticals Inc. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| form 4 | Form 4 — Oliveto Joseph | View Filing | |
| form 4 | Form 4 — Oliveto Joseph | View Filing | |
| form 4 | Form 4 — Oliveto Joseph | View Filing | |
| form 4 | Form 4 — Muller Lorenz | View Filing | |
| form 4 | Form 4 — Muller Lorenz | View Filing | |
| form 4 | Form 4 — Muller Lorenz | View Filing | |
| form 4 | Form 4 — Hasija Amit | View Filing | |
| form 4 | Form 4 — Hasija Amit | View Filing | |
| form 4 | Form 4 — Hasija Amit | View Filing | |
| form 4 | Form 4 — Bharucha David | View Filing | |
| form 4 | Form 4 — Bharucha David | View Filing | |
| form 4 | Form 4 — Bharucha David | View Filing | |
| form 4 | Form 4 — Nelson Jeffrey Edward | View Filing | |
| form 4 | Form 4 — Nelson Jeffrey Edward | View Filing | |
| form 4 | Form 4 — Nelson Jeffrey Edward | View Filing | |
| edgar index | 8-K — Milestone Pharmaceuticals Inc. | View Filing | |
| eight k text | 8-K — 8-K | View Filing | |
| edgar index | 4 — Milestone Pharmaceuticals Inc. | View Filing | |
| edgar index | 144 — Milestone Pharmaceuticals Inc. | View Filing | |
| form 4 | Form 4 — Oliveto Joseph | View Filing | |
| edgar index | 144 — Milestone Pharmaceuticals Inc. | View Filing | |
| form 4 | Form 4 — Oliveto Joseph | View Filing | |
| edgar index | 8-K — Milestone Pharmaceuticals Inc. | View Filing | |
| eight k text | 8-K — 8-K | View Filing |