Milestone Pharmaceuticals (MIST)

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Milestone Pharmaceuticals Inc. is a biopharmaceutical company centred on cardiovascular medicines, with a particular focus on episodic conditions that may benefit from rapid, patient-administered treatment outside the hospital. Its business is built around etripamil, a calcium channel blocker formulated as a nasal spray and commercialised in the United States under the CARDAMYST brand.

CARDAMYST is designed for people with paroxysmal supraventricular tachycardia, or PSVT, a condition marked by sudden episodes of abnormally fast heart rhythm that can cause palpitations, dizziness, shortness of breath, chest discomfort, and anxiety. Traditional management of acute PSVT often involves medical supervision, vagal manoeuvres, emergency care, or intravenous therapy. Milestone’s approach is distinctive because it aims to give appropriate patients a portable treatment option that can be used when an attack occurs, rather than requiring immediate administration in a clinical setting.

The company’s strategy combines drug development, regulatory execution, and commercial preparation in a single specialised area of cardiovascular care. By focusing on a defined arrhythmia population, Milestone seeks to address a practical gap between chronic prevention and emergency intervention. The nasal delivery route is central to the product’s positioning, as it is intended to provide a non-invasive and convenient means of administering therapy during intermittent episodes.

Milestone operates as one reportable segment, reflecting its narrow concentration on cardiovascular product development and commercialisation. For investors, the company offers exposure to a targeted specialty pharmaceutical model. Its prospects depend on physician adoption, patient education, reimbursement, post-approval evidence, and the broader acceptance of self-administered acute therapy for PSVT.

1.29 USD
1.29 USD
+0.01 (+0.78%)
Pre-market

Last updated

Market Cap
160.6M
P/E
P/FCF
P/S
90.02
Enterprise Value
225.59M
Sector
Health Care
Industry
Pharmaceutical Preparations
Address
1111 BOUL. DR.-FREDERIK-PHILIPS, STE 420, MONTREAL, A8, H4M 2X6
GlobeNewswire Inc.

Milestone Pharmaceuticals Announces RESET-PSVT Registry to Generate Real-World Evidence on CARDAMYST™ (etripamil) Nasal Spray in Patients With PSVT

10-Apr-2026, 17:00 PM
GlobeNewswire Inc.

Milestone Receives FDA Approval of CARDAMYST™ (etripamil) as First and Only Self-Administered Nasal Spray for Adults with Paroxysmal Supraventricular Tachycardia (PSVT)

13-Dec-2025, 06:00 AM
GlobeNewswire Inc.

Milestone Pharmaceuticals to Present New Analysis from Investigational Etripamil Nasal Spray Clinical Trials for PSVT at the American Heart Association Scientific Sessions 2025

03-Nov-2025, 18:00 PM
GlobeNewswire Inc.

Milestone® Pharmaceuticals to Present Data on Etripamil at the American Heart Association Scientific Sessions 2025

09-Oct-2025, 17:00 PM
GlobeNewswire Inc.

Atrial Fibrillation (AF) Pipeline Market Research Report 2025 | Insights on 10+ Companies and 12+ Drugs in the Pipeline Landscape

25-Jul-2025, 19:55 PM
GlobeNewswire Inc.

Milestone Pharmaceuticals Announces FDA Acceptance of the Company’s Response to the CRL for CARDAMYST™ (etripamil) Nasal Spray

11-Jul-2025, 15:00 PM
GlobeNewswire Inc.

Milestone Partner Ji Xing Pharmaceuticals Ltd Announces Positive Topline Results from the Phase 3 Study of Etripamil in PSVT in China

06-Sept-2024, 16:00 PM
GlobeNewswire Inc.

Milestone Pharmaceuticals to Host KOL Event for Investors “Learnings from the Field: Expert Perspectives on PSVT in the Community Setting” on June 20, 2024

12-Jun-2024, 17:00 PM
GlobeNewswire Inc.

Milestone® Pharmaceuticals to Participate in the Upcoming Jefferies Global Healthcare Conference

31-May-2024, 17:00 PM
GlobeNewswire Inc.

Milestone Pharmaceuticals Announces FDA Acceptance of New Drug Application for CARDAMYST™

29-May-2024, 16:00 PM
Zacks Investment Research

Milestone Pharmaceuticals (MIST) Upgraded to Buy: Here's What You Should Know

16-May-2024, 21:00 PM
GlobeNewswire Inc.

Milestone Pharmaceuticals Reports First Quarter 2024 Financial Results and Provides Regulatory and Corporate Update

13-May-2024, 16:15 PM
GlobeNewswire Inc.

Milestone® Pharmaceuticals to Present Data on Etripamil at the Preventative Cardiovascular Nursing Symposium

17-Apr-2024, 17:00 PM
GlobeNewswire Inc.

Milestone® Pharmaceuticals Announces Etripamil Data Demonstrating Patients’ Ability to Self-Manage Recurring PSVT, Presented at The American College of Cardiology Annual Meeting

08-Apr-2024, 20:36 PM
GlobeNewswire Inc.

Milestone® Pharmaceuticals to Present Data on Etripamil at the American College of Cardiology and European Heart Rhythm Association Annual Conferences

01-Apr-2024, 17:00 PM
GlobeNewswire Inc.

Milestone Pharmaceuticals Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Regulatory and Corporate Update

21-Mar-2024, 16:14 PM
GlobeNewswire Inc.

Milestone® Pharmaceuticals to Participate in a Corporate Panel Discussion at TD Cowen 44th Annual Health Care Conference

01-Mar-2024, 02:01 AM
GlobeNewswire Inc.

Milestone Pharmaceuticals Announces Pricing of $30.0 Million Public Offering of Common Shares and Pre-Funded Warrants

29-Feb-2024, 17:00 PM
GlobeNewswire Inc.

Milestone Pharmaceuticals Announces Proposed Public Offering of Common Shares and Pre-Funded Warrants

29-Feb-2024, 02:37 AM
Zacks Investment Research

Down -43.64% in 4 Weeks, Here's Why Milestone Pharmaceuticals (MIST) Looks Ripe for a Turnaround

16-Jan-2024, 19:35 PM
Market Cap
160.6M
Enterprise Value
225.59M
P/E
P/B
-8.19
P/S
90.02
EV / EBITDA
-3.46
EV / Sales
126.45
EPS
-0.55
Dividend Yield
0%
P/FCF
P/CF
Free Cash Flow
-51.48M
ROE
348.79%
ROA
-35.29%
Debt / Equity
-6.95
Current Ratio
9.18
Quick Ratio
9.09
Cash
3.41
Avg Volume
1.3M
Fundamentals Snapshot Price
1.29

Income Statement

Line Item 2026 Q1 2025 Q4 2025 Q3 2025 Q2 2025 Q1
Revenue 238K 1.55M
Gross profit 224K 1.55M
Operating income -23.66M -17.26M -11.83M -12.53M -20.52M
EBITDA -23.61M -17.22M -11.8M -12.5M -20.5M
Net income -26.07M -17.41M -11.92M -12.97M -20.76M
Basic EPS -0.2 -0.15 -0.12 -0.2 -0.31
Diluted EPS -0.2 -0.15 -0.12 -0.2 -0.31

Balance Sheet

Line Item 2026 Q1 2025 Q4 2025 Q3 2025 Q2 2025 Q1
Total assets 193.73M 113.56M 87.75M 47.42M 61.89M
Total liabilities 213.33M 127.44M 122.9M 65.16M 121.08M
Total equity -19.6M -13.88M -35.15M -17.75M -59.2M
Cash & equivalents 71.32M 73.05M 46.69M 42.5M 45.09M
Current assets 192.25M 111.92M 86.67M 46.17M 60.48M
Current liabilities 20.94M 13.98M 10.52M 9.28M 12.96M

Cash Flow

Line Item 2026 Q1 2025 Q4 2025 Q3 2025 Q2 2025 Q1
Operating cash flow -16.05M -12.78M -9.75M -12.57M -13.95M
Investing cash flow -80.03M 2.7M -34.98M 9.94M 33.58M
Financing cash flow 94.35M 36.43M 48.92M 36K 140K
Change in cash -1.73M 26.36M 4.19M -2.59M 19.77M
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form 4 Form 4 — Bharucha David View Filing
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form 4 Form 4 — Nelson Jeffrey Edward View Filing
form 4 Form 4 — Nelson Jeffrey Edward View Filing
form 4 Form 4 — Nelson Jeffrey Edward View Filing
edgar index 8-K — Milestone Pharmaceuticals Inc. View Filing
eight k text 8-K — 8-K View Filing
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edgar index 144 — Milestone Pharmaceuticals Inc. View Filing
form 4 Form 4 — Oliveto Joseph View Filing
edgar index 144 — Milestone Pharmaceuticals Inc. View Filing
form 4 Form 4 — Oliveto Joseph View Filing
edgar index 8-K — Milestone Pharmaceuticals Inc. View Filing
eight k text 8-K — 8-K View Filing